God, I miss cheese

[Prometheus]

[ant-mac]

God, I miss cheese

Can't you get hold of any where you live?

[Prometheus]

May 2, 2022 2:37:27 GMT ant-mac said:

God, I miss cheese

Can't you get hold of any where you live?

Sometimes you can come across some cheddar or monteray jack. You can always find packaged slices and some shredded "mozzarella" but real cheese? Not so much and when you do, it's expensive.

[ant-mac]

May 2, 2022 4:38:47 GMT Prometheus said:

May 2, 2022 2:37:27 GMT ant-mac said:

Can't you get hold of any where you live?

Sometimes you can come across some cheddar or monteray jack. You can always find packaged slices and some shredded "mozzarella" but real cheese? Not so much and when you do, it's expensive.

You poor bugger... I had no idea you were doing it so tough.

I've seen an aging Asian Doctor from time to time, who found dairy products in general disgusting.

I didn't have the heart to tell him I found most seafood equally disgusting.

[abbey1227]

May 2, 2022 2:37:27 GMT ant-mac said:

God, I miss cheese

Can't you get hold of any where you live?

I used to think, like strip malls, that most of the US was sort of a copycat of stores and supplies, especially in grocery stores.

But then a GF moved from here to Virginia Beach and discovered that not only could she not find bratwurst, they'd never heard of it. Cheese products were also a problem.

[ant-mac]

May 2, 2022 6:16:20 GMT abbey1227 said:

May 2, 2022 2:37:27 GMT ant-mac said:

Can't you get hold of any where you live?

I used to think, like strip malls, that most of the US was sort of a copycat of stores and supplies, especially in grocery stores.

But then a GF moved from here to Virginia Beach and discovered that not only could she not find bratwurst, they'd never heard of it. Cheese products were also a problem.

It's a similar case here in Australia... or at least it used to be.

There were noticeable differences in what you could get in different states.

Many brands were universal, but there were also some that weren't.

[Prometheus]

May 2, 2022 4:49:27 GMT ant-mac said:

May 2, 2022 4:38:47 GMT Prometheus said:

Sometimes you can come across some cheddar or monteray jack. You can always find packaged slices and some shredded "mozzarella" but real cheese? Not so much and when you do, it's expensive.

You poor bugger... I had no idea you were doing it so tough.

I've seen an aging Asian Doctor from time to time, who found dairy products in general disgusting.

I didn't have the heart to tell him I found most seafood equally disgusting.

Asians are - for the most part - lactose intolerant.

[Prometheus]

May 2, 2022 6:16:20 GMT abbey1227 said:

May 2, 2022 2:37:27 GMT ant-mac said:

Can't you get hold of any where you live?

I used to think, like strip malls, that most of the US was sort of a copycat of stores and supplies, especially in grocery stores.

But then a GF moved from here to Virginia Beach and discovered that not only could she not find bratwurst, they'd never heard of it. Cheese products were also a problem.

mmmmm brats....

Back home, my friend Larry hosted an annual summer party he called, "Sausage Fest."

The only meat allowed was sausages... brats... chouriso... Italian... etc. and all the guests were male. We'd pitch horseshoes, play poker, drink, smoke, fart, and tell all the dirty jokes our wives/girlfriends would never have approved of.

And that party became popular. It started off with just about 8 guys, and by the last one that I went to, it was around 30 guys. There were about 5 grills going and we had a great time.

[ant-mac]

May 2, 2022 23:10:26 GMT Prometheus said:

May 2, 2022 4:49:27 GMT ant-mac said:

You poor bugger... I had no idea you were doing it so tough.

I've seen an aging Asian Doctor from time to time, who found dairy products in general disgusting.

I didn't have the heart to tell him I found most seafood equally disgusting.

Asians are - for the most part - lactose intolerant.

Oh well, we all have our various strengths and weaknesses. 

[Prometheus]

May 3, 2022 2:00:13 GMT ant-mac said:

May 2, 2022 23:10:26 GMT Prometheus said:

Asians are - for the most part - lactose intolerant.

Oh well, we all have our various strengths and weaknesses. 

and gaseous outbursts....

[ant-mac]

May 3, 2022 2:04:09 GMT Prometheus said:

May 3, 2022 2:00:13 GMT ant-mac said:

Oh well, we all have our various strengths and weaknesses. 

and gaseous outbursts....

In that department, not all men were made equal. 

[Prometheus]

May 3, 2022 2:06:44 GMT ant-mac said:

May 3, 2022 2:04:09 GMT Prometheus said:

and gaseous outbursts....

In that department, not all men were made equal. 

True dat.

[abbey1227]

May 2, 2022 23:21:42 GMT Prometheus said:

May 2, 2022 6:16:20 GMT abbey1227 said:

I used to think, like strip malls, that most of the US was sort of a copycat of stores and supplies, especially in grocery stores.

But then a GF moved from here to Virginia Beach and discovered that not only could she not find bratwurst, they'd never heard of it. Cheese products were also a problem.

mmmmm brats....

Back home, my friend Larry hosted an annual summer party he called, "Sausage Fest."

The only meat allowed was sausages... brats... chouriso... Italian... etc. and all the guests were male. We'd pitch horseshoes, play poker, drink, smoke, fart, and tell all the dirty jokes our wives/girlfriends would never have approved of.

And that party became popular. It started off with just about 8 guys, and by the last one that I went to, it was around 30 guys. There were about 5 grills going and we had a great time.

Gotta love an amusing double entendre

[abbey1227]

May 2, 2022 23:10:26 GMT Prometheus said:

May 2, 2022 4:49:27 GMT ant-mac said:

You poor bugger... I had no idea you were doing it so tough.

I've seen an aging Asian Doctor from time to time, who found dairy products in general disgusting.

I didn't have the heart to tell him I found most seafood equally disgusting.

Asians are - for the most part - lactose intolerant.

it's not in tune with evolution.........

[Prometheus]

May 3, 2022 4:18:23 GMT abbey1227 said:

May 2, 2022 23:10:26 GMT Prometheus said:

Asians are - for the most part - lactose intolerant.

it's not in tune with evolution.........

Great movie!

[abbey1227]

May 3, 2022 23:56:51 GMT Prometheus said:

May 3, 2022 4:18:23 GMT abbey1227 said:

it's not in tune with evolution.........

Great movie!

I don't know if I'd ever hear about that lactose intolerance before.....but it makes sense to me diet-wise.

Then this morning I'm rewatching a stand up bit from Rob Schneider and he shouts at the young people "I'm 50 people! If I wanna get F'd up these days? I eat some cheese." 

[merh]

Effect of Cheese Intake on Cardiovascular Diseases and Cardiovascular Biomarkers
by Meng-Jin Hu,Jiang-Shan Tan,Xiao-Jin Gao,Jin-Gang Yang andYue-Jin Yang *ORCID
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
*
Author to whom correspondence should be addressed.
Academic Editors: Rosa Casas and Lindsay Brown
Nutrients 2022, 14(14), 2936; doi.org/10.3390/nu14142936
Received: 14 June 2022 / Revised: 11 July 2022 / Accepted: 14 July 2022 / Published: 18 July 2022
(This article belongs to the Special Issue The Relationship between Physical Activity, Food Intake and Metabolic Diseases)
Download PDF Browse Figures Citation Export
Abstract
Background: A growing number of cohort studies revealed an inverse association between cheese intake and cardiovascular diseases, yet the causal relationship is unclear. Objective: To assess the causal relationship between cheese intake, and cardiovascular diseases and cardiovascular biomarkers. Methods: A two-sample Mendelian randomization (MR) analysis based on publicly available genome-wide association studies was employed to infer the causal relationship. The effect estimates were calculated using the random-effects inverse-variance-weighted method. Results: Cheese intake per standard deviation increase causally reduced the risks of type 2 diabetes (odds ratio (OR) = 0.46; 95% confidence interval (CI), 0.34–0.63; p = 1.02 × 10−6), heart failure (OR = 0.62; 95% CI, 0.49–0.79; p = 0.0001), coronary heart disease (OR = 0.65; 95% CI, 0.53–0.79; p = 2.01 × 10−5), hypertension (OR = 0.67; 95% CI, 0.53–0.84; p = 0.001), and ischemic stroke (OR = 0.76; 95% CI, 0.63–0.91; p = 0.003). Suggestive evidence of an inverse association between cheese intake and peripheral artery disease was also observed. No associations were observed for atrial fibrillation, cardiac death, pulmonary embolism, or transient ischemic attack. The better prognosis associated with cheese intake may be explained by lower body mass index (BMI; effect estimate = −0.58; 95% CI, from −0.88 to −0.27; p = 0.0002), waist circumference (effect estimate = −0.49; 95% CI, from −0.76 to −0.23; p = 0.0003), triglycerides (effect estimate = −0.33; 95% CI, from −0.50 to −0.17; p = 4.91 × 10−5), and fasting glucose (effect estimate = −0.20; 95% CI, from −0.33 to −0.07; p = 0.0003). There was suggestive evidence of a positive association between cheese intake and high-density lipoprotein. No influences were observed for blood pressure or inflammation biomarkers. Conclusions: This two-sample MR analysis found causally inverse associations between cheese intake and type 2 diabetes, heart failure, coronary heart disease, hypertension, and ischemic stroke.
Keywords: cheese intake; cardiovascular diseases; biomarkers; Mendelian randomization; causal association
1. Introduction
Dairy fat is characterized by a rich content of saturated fatty acids, which are known to elevate the level of low-density lipoprotein (LDL) cholesterol, thereby the risk of cardiovascular diseases. Correspondingly, the dietary guidelines from both the American Heart Association and the European Society of Cardiology recommend lowering the intake of saturated fat, and only low-fat dairy products are suggested [2,3]. Surprisingly, a meta-analysis including 12 prospective cohort studies demonstrated no significant increases in cardiovascular diseases for a high intake of saturated fat compared with a low intake of it. Another meta-analysis including 21 prospective studies also found no significant associations between dietary saturated fat intake and the risks of coronary heart disease, stroke, or cardiovascular diseases. In addition, specific dairy foods may play different roles in the development of cardiovascular diseases. For example, the extensive European Investigation into Cancer and Nutrition (EPIC) cohort involving 340,234 participants across eight European countries revealed that milk intake had no associations with type 2 diabetes, while cheese intake was inversely associated with the risk of diabetes (relative ratio (RR) = 0.83; 95% CI, 0.70–0.98; p = 0.003) [6]. Similarly, other observational studies also found no or even inverse correlation between cheese intake and cardiovascular diseases, although cheese is usually regarded as a full-fat dairy product [7,8,9]. However, as these are observational studies in nature, a selection bias may exist, which requires us to interpret the results with caution. Regrettably, no randomized controlled trials with hard endpoints are available on this topic to prove the causality. Such a randomized controlled trial is also highly challenging to be performed in the future. However, considering the fact that dairy accounts for 10% of daily calories in the USA, and cheese takes up 45% of dairy, it is worthwhile to investigate the causal relationship between cheese intake and cardiovascular outcomes.
Currently, the Mendelian randomization (MR) analysis has been widely applied to assess the potential causal relationships between various exposures and clinical outcomes. Compared with traditional observational studies, the MR analysis can overcome reverse causation bias, since allelic randomization always precedes the onset of disease. Moreover, random segregation and the independent assortment of genetic polymorphisms at conception enables the MR analysis to minimize the effect of confounding factors by introducing genetic markers as instrumental variables (IVs) of exposures [11,12]. The availability of large-scale genome-wide association studies (GWASs) further enables the exploration of causality. Therefore, by applying an MR analysis, we are determined to answer the following two key questions: (1) is cheese intake negatively, neutrally, or positively associated with cardiovascular diseases? (2) what is the effect of cheese intake on cardiovascular-related biomarkers?

www.mdpi.com/2072-6643/14/14/2936

Are they playing us?
"Yes, fat Americans! Eat cheese! It is good for you!"
("Hahaha. Die! Die!")

I mean, American dieticians have told us it will clog the arteries.

[abbey1227]

Jul 19, 2022 11:35:19 GMT merh said:

Effect of Cheese Intake on Cardiovascular Diseases and Cardiovascular Biomarkers
by Meng-Jin Hu,Jiang-Shan Tan,Xiao-Jin Gao,Jin-Gang Yang andYue-Jin Yang *ORCID
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
*
Author to whom correspondence should be addressed.
Academic Editors: Rosa Casas and Lindsay Brown
Nutrients 2022, 14(14), 2936; doi.org/10.3390/nu14142936
Received: 14 June 2022 / Revised: 11 July 2022 / Accepted: 14 July 2022 / Published: 18 July 2022
(This article belongs to the Special Issue The Relationship between Physical Activity, Food Intake and Metabolic Diseases)
Download PDF Browse Figures Citation Export
Abstract
Background: A growing number of cohort studies revealed an inverse association between cheese intake and cardiovascular diseases, yet the causal relationship is unclear. Objective: To assess the causal relationship between cheese intake, and cardiovascular diseases and cardiovascular biomarkers. Methods: A two-sample Mendelian randomization (MR) analysis based on publicly available genome-wide association studies was employed to infer the causal relationship. The effect estimates were calculated using the random-effects inverse-variance-weighted method. Results: Cheese intake per standard deviation increase causally reduced the risks of type 2 diabetes (odds ratio (OR) = 0.46; 95% confidence interval (CI), 0.34–0.63; p = 1.02 × 10−6), heart failure (OR = 0.62; 95% CI, 0.49–0.79; p = 0.0001), coronary heart disease (OR = 0.65; 95% CI, 0.53–0.79; p = 2.01 × 10−5), hypertension (OR = 0.67; 95% CI, 0.53–0.84; p = 0.001), and ischemic stroke (OR = 0.76; 95% CI, 0.63–0.91; p = 0.003). Suggestive evidence of an inverse association between cheese intake and peripheral artery disease was also observed. No associations were observed for atrial fibrillation, cardiac death, pulmonary embolism, or transient ischemic attack. The better prognosis associated with cheese intake may be explained by lower body mass index (BMI; effect estimate = −0.58; 95% CI, from −0.88 to −0.27; p = 0.0002), waist circumference (effect estimate = −0.49; 95% CI, from −0.76 to −0.23; p = 0.0003), triglycerides (effect estimate = −0.33; 95% CI, from −0.50 to −0.17; p = 4.91 × 10−5), and fasting glucose (effect estimate = −0.20; 95% CI, from −0.33 to −0.07; p = 0.0003). There was suggestive evidence of a positive association between cheese intake and high-density lipoprotein. No influences were observed for blood pressure or inflammation biomarkers. Conclusions: This two-sample MR analysis found causally inverse associations between cheese intake and type 2 diabetes, heart failure, coronary heart disease, hypertension, and ischemic stroke.
Keywords: cheese intake; cardiovascular diseases; biomarkers; Mendelian randomization; causal association
1. Introduction
Dairy fat is characterized by a rich content of saturated fatty acids, which are known to elevate the level of low-density lipoprotein (LDL) cholesterol, thereby the risk of cardiovascular diseases. Correspondingly, the dietary guidelines from both the American Heart Association and the European Society of Cardiology recommend lowering the intake of saturated fat, and only low-fat dairy products are suggested [2,3]. Surprisingly, a meta-analysis including 12 prospective cohort studies demonstrated no significant increases in cardiovascular diseases for a high intake of saturated fat compared with a low intake of it. Another meta-analysis including 21 prospective studies also found no significant associations between dietary saturated fat intake and the risks of coronary heart disease, stroke, or cardiovascular diseases. In addition, specific dairy foods may play different roles in the development of cardiovascular diseases. For example, the extensive European Investigation into Cancer and Nutrition (EPIC) cohort involving 340,234 participants across eight European countries revealed that milk intake had no associations with type 2 diabetes, while cheese intake was inversely associated with the risk of diabetes (relative ratio (RR) = 0.83; 95% CI, 0.70–0.98; p = 0.003) [6]. Similarly, other observational studies also found no or even inverse correlation between cheese intake and cardiovascular diseases, although cheese is usually regarded as a full-fat dairy product [7,8,9]. However, as these are observational studies in nature, a selection bias may exist, which requires us to interpret the results with caution. Regrettably, no randomized controlled trials with hard endpoints are available on this topic to prove the causality. Such a randomized controlled trial is also highly challenging to be performed in the future. However, considering the fact that dairy accounts for 10% of daily calories in the USA, and cheese takes up 45% of dairy, it is worthwhile to investigate the causal relationship between cheese intake and cardiovascular outcomes.
Currently, the Mendelian randomization (MR) analysis has been widely applied to assess the potential causal relationships between various exposures and clinical outcomes. Compared with traditional observational studies, the MR analysis can overcome reverse causation bias, since allelic randomization always precedes the onset of disease. Moreover, random segregation and the independent assortment of genetic polymorphisms at conception enables the MR analysis to minimize the effect of confounding factors by introducing genetic markers as instrumental variables (IVs) of exposures [11,12]. The availability of large-scale genome-wide association studies (GWASs) further enables the exploration of causality. Therefore, by applying an MR analysis, we are determined to answer the following two key questions: (1) is cheese intake negatively, neutrally, or positively associated with cardiovascular diseases? (2) what is the effect of cheese intake on cardiovascular-related biomarkers?

www.mdpi.com/2072-6643/14/14/2936

Are they playing us?
"Yes, fat Americans! Eat cheese! It is good for you!"
("Hahaha. Die! Die!")

I mean, American dieticians have told us it will clog the arteries.

Totally worth it.

I'll be grilling up some cheddar brats in the next day or so